Scientists have inserted a GIF of a horse into living bacteria -- did your brain just explode?
In a new study
published in Nature, a group of scientists at Harvard have successfully
stored a GIF— yes, like a moving meme — into live bacteria (E. coli to be specific).
It's a weird idea, but scientists have actually been
using the genetic wondertool known as CRISPR or "clustered regularly
interspaced short palindromic repeats" for data storage parlor tricks for some time.
CRISPR, explained in a bit more depth here,
makes all sorts of wild things possible and people are rightfully excited about
it. Those revelations are often reserved for geneticists and health
researchers, but the Harvard experiment and others like it demonstrate CRISPR's
utility even beyond its vast, untapped potential in the world of medicine.
As a very short primer, CRISPR-associated proteins (in
this instance, specifically proteins known as Cas1 and Cas2) act as a DNA
version of a computer's Ctrl-X tool, allowing scientists to pinpoint specific
segments of DNA, cut them out, fiddle with them and even replace them
altogether.
Due to its dynamic,
if brief, nature, encoding the historic horse GIF posed unique challenges over say just
sticking any old static image into living bacteria (though they did that too).
By utilizing Cas1 and Cas2's sequencing abilities, the researchers encoded the
temporal order of the GIF frame by frame and were able to extract and put it
back together with 90 percent accuracy.
As the paper explains:
"When harnessed, this system has the potential to write
arbitrary information into the genome. Here we use the CRISPR–Cas system to encode
the pixel values of black and white images and a short movie into the genomes
of a population of living bacteria. In doing so, we push the technical limits
of this information storage system and optimize strategies to minimize those
limitations."
Remarkably, the
bacteria went on multiplying, apparently unconcerned with its data stowaway,
even passing it along to future generations through its genetic material.
This is
molecular-scale stuff, but the ideas are huge. It's not really about scaling up
the computer hard drives that house our vacation photos, though that's a bonus.
In interviews, lead author Seth Shipman suggests that it's a
proof of concept exercise meant to model a future in which cells record a kind
of living record of their own existences. That record could be accessed and
replayed by anyone who wanted to learn more about how that cell was behaving or
interacting in its environment over time.
If that cell is a neuron, the potential insights into
the human brain are as vast as the 215 petabytes of data researchers have managed to cram
into a single gram of DNA. And if that doesn't knock you out, with similar
techniques, scientists could hypothetically store all of the data ever
generated by the human race in a single room.
"DNA is an excellent medium for archiving
data," the researchers write. No kidding.
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